Perachori, located at an altitude of 300 meters above Vathy, is the largest and one of the oldest villages in Ithaca and the only one on the south side of the island. It seems to have been created during the Venetian domination with and its original position was a bit more east than today. The ruins of the Venetian village of Paleochora are now accessible via a paved path and from there the view is unparalleled, since the clear days from there you can see even the Rio-Antirio Bridge in Patras! The architecture of Paleochora demonstrates the defensive character of the village, which, in the absence of a castle, shields the houses as much as possible to resist the raids. Also in Paleochora we find ten churches, three of which have been characterized as monuments of Byzantine art (the Assumption of Virgin Mary, the Presentation of Virgin Mary and the church of Saint John).

Nowadays in Perachori there is the holy temple of Saint Raphael who was born here in 1410 and found a mortal death in Lesvos in 1463. The temple that was completed in 1980 is built in a polygonal style and its wood-carved iconostasis dating from the 17th century was transferred from the temple of the Assumption of Virgin Mary in Paleochora, which was destroyed by the earthquakes of 1953.

In the area of ??Vouni, at a distance of two kilometers outside the village, there is the Taxiarches Monastery built in 1613 and celebrates on July 13, while a big feast is held on this eve. On the way to the Monastery, there are stone threshing floor where the grain was stamped for the fruit to come out.

Perachori is one of the less tourist villages on the island, as the area has water that is missing from most of the other parts of Ithaca and is fertile, with the result that residents have the opportunity to engage in agriculture and livestock farming. However, a visitor can admire the magnificent view from some of its taverns that offer authentic flavors, and of course not to miss the wine festival held here on the last Saturday of July!